China (Mainland)
Everolimus CAS NO.159351-69-6
- Min.Order: 100 Gram
- Payment Terms: L/C,D/P,T/T,Other
- Product Details
Keywords
- Everolimus powde
- Certica
- Everolimus solution
Quick Details
- ProName: Everolimus
- CasNo: 159351-69-6
- Molecular Formula: C53H83NO14
- Appearance: White to yellowish powder
- Application: Tumor medicine
- DeliveryTime: 60 days after the signing of the contr...
- PackAge: Aluminum foil bag or drum
- Port: Any port in China
- ProductionCapacity: Metric Ton/Day
- Purity: 98% or more
- Storage: -6 ° C seal preservation
- Transportation: transportshipment is allow
- LimitNum: 100 Gram
Superiority
Sunitinib and Solafenib are multiple kinase inhibitors(acting on multiple cell targets), while everolimus blocks the specific protein of the mammalian Rapamycin Target(mTOR), interfering the growth, differentiation and metabolism of cancer cells. This mTOR pathway regulates abnormally in some people. everolimus binds to intracellular protein FKBP12 to form an inhibitory complex, thereby inhibiting mTOR kinase activity, while reducing the activity of the mTOR downstream effector S6 ribosome kinase(S6K1)and eukaryotic extension factor 4E binding protein(4EBP). In addition, everolimus inhibited the expression of hypoxic inducible factors(e.g., HIF1)and decreased the expression of vascular endothelial growth factor(VEGF), both in vitro and in vivo studies have shown that reduced cellular hyperplasia, angiogenesis, and glucose uptake.